Endocrine Abstracts

Introduction: Insulin-like growth factor-I (IGF-I) has a role in cell proliferation, differentiation, migration, and survival. By alternative splicing different IGF-I mRNA transcripts as IGF-IEc (mechano growth factor, MGF) or IGF-IEa variants are produced. MGF induces muscle hypertrophy and implicated in the pathophysiology of various types of cancer. Aim of the study was to investigate the role of MGF in the pathophysiology of neuroendocrine neoplasms (NENs).<p class="ab...